Blood transfusion usage among adults with sickle cell disease – a single institution experience over ten years

@article{Draar2011BloodTU,
  title={Blood transfusion usage among adults with sickle cell disease – a single institution experience over ten years},
  author={Emma R Dra{\vs}ar and Norris Igbineweka and Nisha Vasavda and Matthew D Free and Moji Awogbade and Marlene Allman and Aleksandar Mijovic and Swee Lay Thein},
  journal={British Journal of Haematology},
  year={2011},
  volume={152}
}
Transfusion of red blood cells is a major therapeutic option in sickle cell disease (SCD). There is strong evidence for its efficacy, particularly in primary and secondary stroke prevention in children, however, its use in other areas remains controversial. This study assessed the patterns of transfusion in the adult cohort attending King’s College Hospital over a 10‐year period, from 2000 to 2009. Total blood usage has increased significantly (P = 0·006) during this time, with 78% of the blood… Expand
Blood utilization and characteristics of patients treated with chronic transfusion therapy in a large cohort of Brazilian patients with sickle cell disease.
TLDR
Red blood cell transfusion was common in Brazilian SCD patients, with utilization driven by CTT, highlighting the need for novel clinical strategies to mitigate these risks. Expand
Older red cell units are associated with an increased incidence of infection in chronically transfused adults with sickle cell disease.
TLDR
There is evidence that receipt of older units is associated with a higher rate of admission for infection and potential mechanisms by which these older units promote infection. Expand
Transfusion therapy for sickle cell disease
The clinical presentations of sickle cell disease include acute pain, acute chest syndrome, stroke and acute anaemia and blood transfusion therapy can be used effectively in the emergency setting forExpand
Chronic transfusion therapy for stroke in sickle cell disease
TLDR
Based on the results of randomized clinical trials for primary (STOP, STOP II) and secondary stroke prevention (SWiTCH and SIT) in SCA, regular blood transfusion therapy has now become the primary evidence-based option for prevention of infarct recurrence for potentially 40% of all children with SCA. Expand
A study of blood transfusion in sickle cell anaemia patients in South-South Nigeria
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S (HbS). The most common and severe form of SCD found inExpand
Early occurrence of red blood cell alloimmunization in patients with sickle cell disease
TLDR
Older age at first transfusion, episodic transfusions and non‐extended matched transfusions appeared to be risk factors for alloimmunization, substantiating suggestions of a responder phenotype in SCD and stressing the need for risk factor identification. Expand
Sickle cell disease: when and how to transfuse.
  • J. Howard
  • Medicine
  • Hematology. American Society of Hematology. Education Program
  • 2016
TLDR
Questions about when and how to transfuse in SCD remain and will need further randomized trials to provide answers, and the risks and benefits of transfusion should be fully discussed with patients/families before a long-term transfusion program is commenced. Expand
Prevalence of blood transfusion in sickle cell anaemia patients in South-South Nigeria: A two-year experience
TLDR
Efforts must be made to reduce the frequency of blood transfusion by preventive measures such as early diagnosis, regular follow-up, malaria prophylaxis and folic acid usage. Expand
Impact of red blood cell alloimmunization on sickle cell disease mortality: a case series
TLDR
Although red blood cell (RBC) transfusion represents an integral component of sickle cell disease (SCD) care, transfusion support for some patients can result in alloimmunization to RBC antigens, which may result in worse survival compared to nonalloimmunized patients. Expand
How we treat delayed haemolytic transfusion reactions in patients with sickle cell disease
TLDR
An increase in DHTR events in SCD patients with the increasing use of red blood cell transfusion therapy is anticipated, and DHTR must be considered in any recently transfused patient presenting with acute sickle cell pain. Expand
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TLDR
Red cell transfusion is currently the most studied and accepted therapy for most acute and many chronic complications of SCD and Physicians caring for patients with sickle cell disease should be aware of the unique complications and transfusion requirements in this population. Expand
Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease.
TLDR
Discontinuation of transfusion for the prevention of stroke in children with sickle cell disease results in a high rate of reversion to abnormal blood-flow velocities on Doppler studies and stroke. Expand
A prophylactic transfusion program for children with sickle cell anemia complicated by CNS infarction
TLDR
A periodic transfusion program was begun at the Children's Hospital of Michigan in 1969 and of 15 children currently on the program, none have had progression of neurologic abnormalities, and several have had definite improvement in neurologic function. Expand
Systematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease
TLDR
A systematic review of the available data on the efficacy, effectiveness, toxicity, and barriers to the use of hydroxyurea in people with sickle cell disease found that repeated transfusions of red blood cells can greatly decrease disease severity and hematopoietic stem cell transplantation can cure it. Expand
Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.
TLDR
Transfusion greatly reduces the risk of a first stroke in children with sickle cell anemia who have abnormal results on transcranial Doppler ultrasonography. Expand
Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.
TLDR
Hydroxyurea therapy can ameliorate the clinical course of sickle cell anemia in some adults with three or more painful crises per year and Maximal tolerated doses of hydroxyurea may not be necessary to achieve a therapeutic effect. Expand
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TLDR
The progress in amelioration of symptoms, problems unique to particular age groups, and the types of drugs and treatments currently under investigation are discussed. Expand
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TLDR
A treatment protocol that included matched transfusions, bronchodilators, and bronchoscopy was evaluated and it was found that infection and fat embolism are underdiagnosed in patients with the syndrome. Expand
Transfusion prevents acute chest syndrome predicted by elevated secretory phospholipase A2
TLDR
It is suggested that transfusion may prevent acute pulmonary injury in patients with sickle cell disease and red blood cell transfusion can be used to prevent ACS. Expand
Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia.
TLDR
It is demonstrated that chronic transfusion is highly effective in reducing the risk of stroke in children with sickle-cell disease and an abnormal transcranial Doppler ultrasonography examination result. Expand
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