Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier.

@article{Nakashima2004BloodtoretinaTO,
  title={Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier.},
  author={Toshihisa Nakashima and Masatoshi Tomi and Kazunori Katayama and Masanori Tachikawa and Masahiko Watanabe and Tetsuya Terasaki and Ken-Ichi Hosoya},
  journal={Journal of neurochemistry},
  year={2004},
  volume={89 6},
  pages={1454-61}
}
The purpose of this study was to elucidate the mechanisms of blood-to-retina creatine transport across the blood-retinal barrier (BRB) in vivo and in vitro, and to identify the responsible transporter(s). The creatine transport across the BRB in vivo and creatine uptake in an in vitro model of the inner BRB (TR-iBRB2 cells) were examined using [(14)C]creatine. Identification and localization of the creatine transporter (CRT) were carried out by RT-PCR, western blot, and immunoperoxidase… CONTINUE READING