Blood-to-retina transport of biotin via Na+-dependent multivitamin transporter (SMVT) at the inner blood-retinal barrier.

@article{Ohkura2010BloodtoretinaTO,
  title={Blood-to-retina transport of biotin via Na+-dependent multivitamin transporter (SMVT) at the inner blood-retinal barrier.},
  author={Yumiko Ohkura and Shin-ichi Akanuma and Masanori Tachikawa and Ken-Ichi Hosoya},
  journal={Experimental eye research},
  year={2010},
  volume={91 3},
  pages={387-92}
}
The purpose of this study was to elucidate the mechanisms of biotin transport across the inner blood-retinal barrier (inner BRB). [(3)H]Biotin transport in the retina across the inner BRB was examined using an in vivo integration plot and retinal uptake index analyses in rats. The transport mechanism was characterized using a conditionally immortalized rat retinal capillary endothelial cell line (TR-iBRB2 cells) as an in vitro inner BRB model. The apparent influx permeability clearance (K(in… CONTINUE READING

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