Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum.

@article{Garavito2007BloodSA,
  title={Blood schizontocidal activity of methylene blue in combination with antimalarials against Plasmodium falciparum.},
  author={G. Garavito and S. Bertani and J. Rinc{\'o}n and S. Maurel and M. Monje and I. Landau and A. Valentin and E. Deharo},
  journal={Parasite},
  year={2007},
  volume={14 2},
  pages={
          135-40
        }
}
Methylene blue (MB) is the oldest synthetic antimalarial. It is not used anymore as antimalarial but should be reconsidered. For this purpose we have measured its impact on both chloroquine sensitive and resistant Plasmodium strains. We showed that around 5 nM of MB were able to inhibit 50% of the parasite growth in vitro and that late rings and early trophozoites were the most sensitive stages; while early rings, late trophozoites and schizonts were less sensitive. Drug interaction study… Expand
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