Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system.

@article{Fletcher2002BloodPR,
  title={Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system.},
  author={Eugene C. Fletcher and Natalia Orolinova and Michael Bader},
  journal={Journal of applied physiology},
  year={2002},
  volume={92 2},
  pages={627-33}
}
By using an inspired oxygen fraction that produces oxyhemoglobin desaturation equivalent to that seen in human sleep apnea, we have demonstrated that 35 days of recurrent episodic hypoxia (every 30 s for 7 h/day) results in an 8-13 mmHg persistent increase in diurnal systemic mean arterial blood pressure (MAP) in rats. Blockade of angiotensin II receptors (AT(1a)) eliminates this response. Separate groups of male Sprague-Dawley rats were fed high-salt (8%), ad libitum-salt, or low-salt (0.1… CONTINUE READING
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