Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study.

@article{Sica2012BloodPE,
  title={Blood pressure-lowering efficacy of the fixed-dose combination of azilsartan medoxomil and chlorthalidone: a factorial study.},
  author={Domenic A. Sica and George L Bakris and William B White and Michael D Weber and William C. Cushman and Patrick Huang and Andrew Roberts and Stuart F Kupfer},
  journal={Journal of clinical hypertension},
  year={2012},
  volume={14 5},
  pages={284-92}
}
This study compared the efficacy and safety of fixed-dose combinations (FDCs) of the angiotensin II receptor blocker azilsartan medoxomil (AZL-M) and the thiazide-like diuretic chlorthalidone (CLD) with the individual monotherapies in a double-blind factorial study. A total of 1714 patients with clinic systolic blood pressure (SBP) 160 mm Hg to 190 mm Hg inclusive were randomized to AZL-M 0 mg, 20 mg, 40 mg, or 80 mg and/or chlorthalidone 0 mg, 12.5 mg, or 25 mg. The primary efficacy end point… CONTINUE READING
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