Blood pressure lowering efficacy of diuretics as second-line therapy for primary hypertension.

@article{Chen2009BloodPL,
  title={Blood pressure lowering efficacy of diuretics as second-line therapy for primary hypertension.},
  author={Jenny Mh Chen and Balraj S. Heran and James M. Wright},
  journal={The Cochrane database of systematic reviews},
  year={2009},
  volume={4},
  pages={
          CD007187
        }
}
BACKGROUND Diuretics are widely prescribed for hypertension not only as a first-line drug but also as a second-line drug. Therefore, it is essential to determine the effects of diuretics on blood pressure (BP), heart rate and withdrawals due to adverse effects (WDAEs) when given as a second-line drug. OBJECTIVES To quantify the additional reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP) of diuretic therapy as a second-line drug in patients with primary… 

Blood pressure lowering efficacy of beta-blockers as second-line therapy for primary hypertension.

TLDR
Second-line beta-blockers reduce systolic blood pressure to the same extent as second-line thiazide diuretics, but reduce diastolic BP to a greater degree, whereas thiazides cause a significant dose-related decrease in pulse pressure.

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension.

TLDR
ENaC blockers do not have a statistically or clinically significant BP lowering effect at low doses but trials at higher doses are not available, and the review did not provide a good estimate of the incidence of harms associated with ENaC blocker.

Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension.

TLDR
ENaC blockers do not have a statistically or clinically significant BP lowering effect at low doses but trials at higher doses are not available, and the review did not provide a good estimate of the incidence of harms associated with ENaC blocker.

Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension.

TLDR
The dose-related decrease in systolic and/or diastolic blood pressure due to thiazide diuretics compared with placebo control in the treatment of patients with primary hypertension was determined.

Blood pressure-lowering efficacy of loop diuretics for primary hypertension.

TLDR
The quality of evidence was graded as "low" due to the high risk of bias of included studies and the high likelihood of publication bias, and no clinically meaningful blood pressure-lowering differences between different drugs within the loop diuretic class were found.

[Antihypertensive drugs in 2010: old and new agents].

  • M. Leeman
  • Medicine, Biology
    Revue medicale de Bruxelles
  • 2010
TLDR
There is no evidence that "new" antihypertensive agents are superior to "old" agents, and the results of ongoing long-term outcome studies will determine the place of aliskiren in the treatment of hypertension.

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TLDR
La majorite des hypertendus requierent plusieurs antihypertenseurs pour controler leur pression arterielle, independamment des molecules utilisees, a partir des resultats des etudes a long terme qui sont en cours.

The evidence-based use of thiazide diuretics in hypertension and nephrolithiasis.

TLDR
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Aliskiren-Hydrochlorothiazide in Combination: Efficacy Review in Mild to Moderate Hypertension

TLDR
The efficacy and safety of aliskiren alone and in the combination with hydrochlorothiazide, an interesting combination partner since their mode of action allows synergistic effects in regard to lowering blood pressure as well as in reducing possible side effects of both drugs.

Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics

TLDR
The clinical pharmacology of thiazide diuretics is reviewed to provide an insight into the mechanisms involved in their antihypertensive and adverse effects, the determinants of drug response and the possible differences in their pharmacodynamic and pharmacokinetic properties in an attempt to improve their clinical use in the treatment of arterial hypertension.

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TLDR
Second-line beta-blockers reduce systolic blood pressure to the same extent as second-line thiazide diuretics, but reduce diastolic BP to a greater degree, whereas thiazides cause a significant dose-related decrease in pulse pressure.

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