Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways.

@article{Shah2009BloodPA,
  title={Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways.},
  author={Abdul Jabbar Shah and Anwar Ul Hassan Gilani},
  journal={Journal of cardiovascular pharmacology},
  year={2009},
  volume={54 1},
  pages={
          38-46
        }
}
This investigation was aimed to provide a pharmacologic basis to the medicinal use of Acorus calamus in cardiovascular disorders. In normotensive anesthetized rats, crude extract of Acorus calamus and its ethylacetate and nHexane fractions caused a fall in mean arterial pressure. In rabbit aorta rings, crude extract was more potent against high K (80 mM), ethylacetate against phenylephrine (1 microM), whereas nHexane fraction was equipotent against both precontractions. Crude extract exhibited… CONTINUE READING
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