Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat.

@article{Eno2000BloodPD,
  title={Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat.},
  author={A. E. Eno and O I Owo and Edisua Hogan Itam and Roseline S Konya},
  journal={Phytotherapy research : PTR},
  year={2000},
  volume={14 4},
  pages={235-9}
}
A crude ethanol extract was prepared from the unripened fruit of Carica papaya. Lethality studies showed a dose-mortality relationship with an LD(50) of 325.2 mg/kg in mice administered i.p. Male albino Wistar rats were randomly divided into three batches (15 rats per batch)-renal, DOCA-salt hypertensives and normotensives. Each batch was further divided into three groups-the untreated, hydrallazine and extract treated groups. The mean arterial blood pressure (MAP) and the heart rate were… CONTINUE READING
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