Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly.

@article{Glodzik2014BloodPD,
  title={Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly.},
  author={Lidia Glodzik and Henry Rusinek and Elizabeth Pirraglia and P. McHugh and Wai Hon Tsui and Schantel Williams and Megan Cummings and Yi Li and Kenneth E Rich and Catherine L. Randall and Lisa Mosconi and R. S. Osorio and John V Murray and Henrik Zetterberg and K Blennow and Mony J de Leon},
  journal={Neurobiology of aging},
  year={2014},
  volume={35 1},
  pages={64-71}
}
In hypertension (HTN), cerebral blood flow regulation limits are changed, and the threshold for blood pressure (BP) at which perfusion is safely maintained is higher. This shift may increase the brain's vulnerability to lower BP in subjects with vascular disease. We investigated whether longitudinal reduction in mean arterial pressure (MAP) was related to changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease in a group of cognitively healthy elderly with and without HTN. The… CONTINUE READING
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