Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension.

@article{Moreau1997BloodPA,
  title={Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension.},
  author={Pierre Moreau and Hnoyuki Takase and C F K{\"u}ng and Sidney Shaw and Thomas Felix L{\"u}scher},
  journal={Hypertension},
  year={1997},
  volume={29 3},
  pages={763-9}
}
Because nitric oxide inhibits the synthesis and vasoconstrictor effect of endothelin-1, the effect of endothelin-1 may be enhanced under conditions of chronic inhibition of nitric oxide synthesis. We studied the effect of chronic therapy with bosentan, a combined endothelin-A/endothelin-B receptor antagonist, on blood pressure and vascular function and structure of small arteries as well as on the reactivity of the aorta in N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension… CONTINUE READING
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