Blood pressure and metabolic effects of ACTH in normotensive and hypertensive man.

@article{Whitworth1983BloodPA,
  title={Blood pressure and metabolic effects of ACTH in normotensive and hypertensive man.},
  author={Judith Ann Whitworth and D. Saines and Rhys Thatcher and Aldona Butkus and Bruce A. Scoggins},
  journal={Clinical and experimental hypertension. Part A, Theory and practice},
  year={1983},
  volume={5 4},
  pages={501-22}
}
ACTH administration (0.5 mg Synacthen Depot I/M 12 hourly for 5 days) significantly increased systolic blood pressure in normotensive subjects (n=6) and mild essential hypertensives (n=6) but not in 2 Addisonian women, indicating that the pressure rise was adrenally dependent. ACTH administration was associated with urinary sodium retention, hypokalaemia, elevation of fasting blood glucose, lymphopaenia and eosinopaenia. Body weight was increased only in the normotensive subjects. Plasma renin… CONTINUE READING

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