Corpus ID: 20304360

Blood pressure and heart rate response evoked by p-hydroxyamphetamine and by p-hydroxynorephedrine II. A quantitative assessment of the role of amphetamine metabolites in acute responses evoked by d-amphetamine.

@article{Simpson1980BloodPA,
  title={Blood pressure and heart rate response evoked by p-hydroxyamphetamine and by p-hydroxynorephedrine II. A quantitative assessment of the role of amphetamine metabolites in acute responses evoked by d-amphetamine.},
  author={L. Simpson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1980},
  volume={213 3},
  pages={
          504-8
        }
}
  • L. Simpson
  • Published 1980
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
At postganglionic sympathetic sites, p-hydroxyamphetamine is neither a receptor agonist nor a receptor antagonist; in addition the drug does not act presynaptically to antagonize or synergize d-amphetamine. p-Hydroxyamphetamine is an indirectly acting sympathomimetic amine with a potency approximately twice that of d-amphetamine. In the rat, a large fraction (approximately 0.5) of d-amphetamine is biotransformed to p-hydroxyamphetamine. However, the rate of biotransformation to p… Expand
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