Blood pressure and cardiac tissue responses to prostacyclin (PGI2) in various species.

@article{Collins1982BloodPA,
  title={Blood pressure and cardiac tissue responses to prostacyclin (PGI2) in various species.},
  author={Gretchen A. Collins and Bernard A. MacLeod and Michael A. Walker},
  journal={Canadian journal of physiology and pharmacology},
  year={1982},
  volume={60 2},
  pages={134-9}
}
The effect of prostacyclin (PGI2) on blood pressure and heart rate (in vivo) and on isolated heart tissue has been investigated in different species. Isolated cardiac tissue had limited responses to PGI2 tested at 10(-13) to 10(-5) M. Cultured neonatal rat heart cells did not respond to PGI2, neither did intact rat hearts or rabbit cardiac tissue. Guinea… CONTINUE READING