Blood pressure, stroke, and coronary heart disease Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias

  title={Blood pressure, stroke, and coronary heart disease Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias},
  author={Stephen MacMahon and Richard Peto and Rory Collins and Jon Godwin and J Cutler and Paul D. Sorlie and R D Abbott and James D. Neaton and Ar. Dyer and Jeremiah Stamler},
  journal={The Lancet},

Combined effect of blood pressure and total cholesterol levels on long-term risks of subtypes of cardiovascular death: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan.

Systolic BP was positively associated with ischemic stroke and intraparenchymal hemorrhage death, and total cholesterol was inversely associated with intraparaelastic hemorrhage, but no significant interactions between BP andTotal cholesterol were observed for stroke.

Pulse Pressure Compared With Other Blood Pressure Indexes in the Prediction of 25-Year Cardiovascular and All-Cause Mortality Rates: The Chicago Heart Association Detection Project in Industry Study

The data indicate that the long-term risk of high BP should be assessed mainly on the basis of SBP or ofSBP and DBP together, not on the based of PP, in apparently healthy adults.

Association between blood pressure level and the risk of myocardial infarction, stroke, and total mortality: the cardiovascular health study.

In this population-based study of older adults, although all measures of blood pressure were strongly and directly related to the risk of coronary and cerebrovascular events, SBP was the best single predictor of cardiovascular events.

Blood pressure and the risk of stroke , cardiovascular disease and all-cause mortality among Japanese : The JPHC Study Running head : Blood Pressure and cardiovascular disease

Compared to contributions of normal BP, highnormal BP, and mild hypertension to the occurrence of stroke events were greater than those made by moderate and severe hypertension, highlighting the importance of primary prevention and of treatment for low to moderate degrees of hypertension.

Underestimation of the importance of blood pressure and cholesterol for coronary heart disease mortality in old age.

Reductions in the risk of coronary heart disease death associated with differences in usual levels of blood pressure or cholesterol at some particular fixed time prior to death were about as great in old age as in middle age.

Association Between Blood Pressure Level and the Risk of Myocardial Infarction, Stroke, and Total Mortality

In those with treated hypertension, the hazard ratios for the association of SBP with the risks for myocardial infarction and stroke were less pronounced than in those without treated hypertension.

Systolic blood pressure, isolated systolic hypertension and risk of coronary heart disease, strokes, cardiovascular disease and all‐cause mortality in the middle‐aged population

Isolated systolic hypertension is an important predictor of death from coronary heart disease, stroke, cardiovascular disease and all causes for women and for men aged 45–64 years, according to a prospective 15-year cohort study of two independent cross-sectional random samples of subjects.



A Longitudinal Study of Coronary Heart Disease

No relation was encountered between body weight, mean blood sugar levels, lipoprotein lipase levels, or diet (other than coffee), and the development of coronary heart disease, and there was no association with job type and no certain relation to physical activity off the job.

Coronary flow reserve and the J curve relation between diastolic blood pressure and myocardial infarction.

The most probable explanation is that subjects who have severe stenosis of the coronary artery as well as hypertension have a poor coronary flow reserve, which makes the myocardium vulnerable to coronary perfusion pressures that are tolerated by patients without ischaemia, particularly at high heart rates.

INTERSALT Study Findings Public Health and Medical Care Implications

IntERSALT cross-population data suggest that, with a 100 mmol/day lower sodium intake over the life span, the average increase in population systolic pressure from age 25 to 55 years would be less by 9 mm Hg, corresponding at age 55 to a 16% lower risk of subsequent coronary death and 23% lowerrisk of stroke death.

Blood pressure and nutrient intake in the United States

Across the population, higher intakes of calcium, potassium, and sodium were associated with lower mean systolic blood pressure and lower absolute risk of hypertension, and Increments of dietary calcium were also negatively correlated with body mass.

Blood pressure, dietary fats, and antioxidants.

The marked elevation of blood pressure at the lowest levels of plasma ascorbic acid and serum Se concentrations supports the hypothesis that antioxidants play a role in the etiology of hypertension.