Blood pressure, stroke, and coronary heart disease Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context

@article{Collins1990BloodPS,
  title={Blood pressure, stroke, and coronary heart disease Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context},
  author={Rory Collins and Richard Peto and Stephen MacMahon and Jon Godwin and Nawab Qizilbash and Patricia R. Hebert and Kim Eberlein and J. O. Taylor and Charles H. Hennekens and Nicholas H. Fiebach},
  journal={The Lancet},
  year={1990},
  volume={335},
  pages={827-838}
}
There are 14 unconfounded randomised trials of antihypertensive drugs (chiefly diuretics or beta-blockers): total 37,000 individuals, mean treatment duration 5 years, mean diastolic blood pressure (DBP) difference 5-6 mm Hg. In prospective observational studies, a long-term difference of 5-6 mm Hg in usual DBP is associated with about 35-40% less stroke and 20-25% less coronary heart disease (CHD). For those dying in the trials, the DBP difference had persisted only 2-3 years, yet an overview… Expand

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This study reported that in patients with preexisting ischemic heart disease lowering diastolic blood pressure to 85–90 mm Hg r duces the incidence of fatal myocardial infarction and the relationship between mortality from myocardia infarctions and diastolics blood pressure was J-shaped. Expand
Factors Influencing the Systolic Blood Pressure Response to Drug Therapy
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Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
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All the classes of blood pressure lowering drugs have a similar effect in reducing CHD events and stroke for a given reduction in blood pressure, indicating that the benefit is explained by blood pressure reduction itself. Expand
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Blood pressure, stroke, and coronary heart disease Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias
TLDR
The DBP results suggest that for the large majority of individuals, whether conventionally "hypertensive" or "normotensive", a lower blood pressure should eventually confer a lower risk of vascular disease. Expand
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