Blood pressure, heart rate, and behavioral responses to psychological "novelty" stress in freely moving rats.

@article{Buuse2001BloodPH,
  title={Blood pressure, heart rate, and behavioral responses to psychological "novelty" stress in freely moving rats.},
  author={Maarten van den Buuse and Saskia A B E van Acker and Marc F J Fluttert and Edo Ronald de Kloet},
  journal={Psychophysiology},
  year={2001},
  volume={38 3},
  pages={490-9}
}
We developed a new model of psychological "open-field" stress in freely moving rats. Blood pressure and heart rate of the rats were measured by radiotelemetry and behavior analyzed by video tracking software. Open-field exposure induced marked increases in blood pressure and heart rate. Repeated daily exposure induced pressor responses that were slightly higher on Day 4 when compared to Day 1. Pretreatment with the beta1-adrenoceptor antagonist atenolol inhibited the tachycardia whereas the… CONTINUE READING

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