Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist

  title={Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist},
  author={G. I. Nezhinskaya and A. L. Vladykin and N. Sapronov},
  journal={Bulletin of Experimental Biology and Medicine},
Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin. Administration of methacin in combination with albumin or C-reactive protein (but not with IgG) abolished the broncholytic effect of methacin. It was probably associated with allosteric antagonism to M2 cholinergic receptors on non-nervous cells, which increased antibody production and mediator response. The concentration of serotonin in mesenteric lymph nodes was high during shock. 


Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines
Results indicate that both neuronal-type Nc and Ms ACh receptors are present on the surface of lymphocytes, to investigate whether ACh in the blood acts on lymphocytes and participates in the modulation of immune responses. Expand
Blockage of Mouse Muscle Nicotinic Receptors by Serotonergic Compounds
It is concluded that 5‐HT and serotonergic agents inhibit, in a non‐competitive manner, the ACh‐current in muscle AChRs by blocking the open receptor‐channel complex. Expand
The non-neuronal cholinergic system in humans: expression, function and pathophysiology.
Its biological and pathobiological roles have to be elucidated in more detail and possibly, new therapeutical targets may become available. Expand
Practical aspects of the ligand-binding and enzymatic properties of human serum albumin.
A tabulation of high-affinity binding sites for both endogenous and exogenous compounds has been made; it could be useful for the above-mentioned purpose, but it could also be of value when trying to predict potential drug interactions at the protein-binding level. Expand
Proximity between 5-HT secreting enteroendocrine cells and lymphocytes in the gut mucosa of rhesus macaques (Macaca mulatta) is suggestive of a role for enterochromaffin cell 5-HT in mucosal immunity
The involvement of serotonin (5-hydroxytryptamine; 5-HT) in immunoregulation has been well documented. Gut mucosa is a large reservoir of 5-HT most of which is attributed to gut endocrine cells. InExpand
A Case for Regulatory B Cells1
A case for the existence of regulatory B cells is made and the possible developmental pathways and functional mechanisms of these B cells are discussed, including the production of regulatory cytokines IL-10 and TGF-β. Expand
IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.
It is demonstrated that IgG Ab produced during the course of an immune response or administered passively can completely suppress IgE-mediated anaphylaxis and that both allergen interception and Fc gammaRIIb-dependent inhibition contribute to in vivo blocking Ab activity. Expand
Enzymes involved in the bioconversion of ester-based prodrugs.
In this review, the most important enzymes involved in the bioconversion of ester-based prodrugs will be discussed in terms of their biology and biochemistry. Expand
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