Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist

@article{Nezhinskaya2008BloodPP,
  title={Blood plasma proteins modulate the broncholytic effects of a muscarinic receptor antagonist},
  author={G. I. Nezhinskaya and A. L. Vladykin and N. Sapronov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2008},
  volume={145},
  pages={55-57}
}
Blood plasma proteins modulated the effects of muscarinic receptor antagonist methacin. Administration of methacin in combination with albumin or C-reactive protein (but not with IgG) abolished the broncholytic effect of methacin. It was probably associated with allosteric antagonism to M2 cholinergic receptors on non-nervous cells, which increased antibody production and mediator response. The concentration of serotonin in mesenteric lymph nodes was high during shock. 

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