Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery.

@article{Meier2014BloodOE,
  title={Blood outgrowth endothelial cells alter remodeling of completely biological engineered grafts implanted into the sheep femoral artery.},
  author={Lee A. Meier and Zeeshan H Syedain and Matthew T Lahti and Sandra A. S. Johnson and Minna Chen and Robert P. Hebbel and Robert T. Tranquillo},
  journal={Journal of cardiovascular translational research},
  year={2014},
  volume={7 2},
  pages={242-9}
}
Hemocompatibility of tissue-engineered vascular grafts remains a major hurdle to clinical utility for small-diameter grafts. Here we assessed the feasibility of using autologous blood outgrowth endothelial cells to create an endothelium via lumenal seeding on completely biological, decellularized engineered allografts prior to implantation in the sheep femoral artery. The 4-mm-diameter, 2- to 3-cm-long grafts were fabricated from fibrin gel remodeled into an aligned tissue tube in vitro by… CONTINUE READING