Blood monocyte concentration is critical for enhancement of collateral artery growth.

  title={Blood monocyte concentration is critical for enhancement of collateral artery growth.},
  author={Matthias Heil and Tibor Ziegelhoeffer and Frederic Pipp and Sawa Kostin and Sandra Martin and Matthias Clauss and Wolfgang Schaper},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={283 6},
Arteriogenesis has been associated with the presence of monocytes/macrophages within the collateral vessel wall. We tested the hypothesis that arteriogenesis is functionally linked to the concentration of circulating blood monocytes. Monocyte concentrations in peripheral blood were manipulated by single injections of the antimetabolite 5-fluorouracil (5-FU), resulting in a marked rebound effect in New Zealand White rabbits. Collateral artery growth was assessed by the use of a model of acute… CONTINUE READING

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