Blood levels and electroencephalographic effects of diazepam and bromazepam

@article{Fink1976BloodLA,
  title={Blood levels and electroencephalographic effects of diazepam and bromazepam},
  author={M Fink and Peter Irwin and Robert E. Weinfeld and Morton A. Schwartz and A. H. Canney},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1976},
  volume={20}
}
Blood levels and electroencephalographic (EEG) data were collected for 2 hr after single oral doses of bromazepam (9 mg), diazepam (10 mg), and placebo in 13 male adult volunteers. Both drugs caused an increase in beta activity (above 13 Hz) and a decrease in alpha activity (9 to 11 Hz) in the EEG. Blood levels of 100 nglml of diazepam or 50 ng Iml of bromazepam were associated with significant changes in EEG beta activity. Temporal changes in the EEG after administration of diazepam or… 

EEG, blood level, and behavioral effects of the antidepressant mianserin (ORG GB-94)

EEG profile analysis shows mianserin to increase frequencies below 6 Hz, decrease those from 7.5 to 15 Hz, and increase frequencies above 18 Hz, a pattern similar to amitriptyline, which is a putative thymoleptic on EEG profile analysis with high cerebral penetrance.

The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration.

A clear relationship between serum benzodiazepine concentration and its effect on a convenient measure of brainstem reticular formation function is demonstrated and is demonstrated in a double-blind randomized fashion.

The influence of bromazepam on cortical power distribution.

Although the expected anxiolytic EEG profile was not observed, this specific result may be related to other factors such as dosage used and the subjects' general physiological state, and not necessarily to the drug itself.

Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers.

It is indicated that it is possible to deliver a clinically effective nasal dose of diazepam for the acute treatment of epilepsy, using PEG300 as a solubilizer.

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo

Electroencephalographic effects of diazepam, midazolam and placebo were indistinguishable from baseline by 6 to 8 hours, suggesting that distribution contributes importantly to terminating pharmacodynamic action.

Electroencephalographic effects of benzodiazepines. I. Choosing an electroencephalographic parameter to measure the effect of midazolam on the central nervous system

It is concluded that the voltage per second from aperiodic analysis provided the electroencephalographic parameter that optimally measured the effect of midazolam on the central nervous system.

Determination of Pharmacodynamics of Diazepam by Quantitative Pharmaco‐EEG

It is concluded that a single administration of DZ causes sedation of a short duration, and the main metabolic product of D Z (metabolite NDDZ) does not seem to contribute to sedation.

Effects of butoctamide hydrogen succinate and nitrazepam on psychomotor function and EEG in healthy volunteers

The results indicated that BAHS, at the dose used, was less potent than nitrazepam and the effects on psychomotor performance and standing steadiness were minimal.

Pharmaco-EEG: A History of Progress and a Missed Opportunity

Following a seminal discussion at the ClNP 1966 meeting, the agreement was reached that the EEGlbehavioral dissociation after anticholinergic drugs reflects the discrepancy between the quantitative assessments of motor behavior and qualitative description of the EEG.
...

References

SHOWING 1-10 OF 21 REFERENCES

Metabolism of diazepam in rat, dog, and man.

Diazepam, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H- 1,4-benzodiazepin-2-one, synthesized and administered to rats, dogs and 2 human subjects revealed that the highest levels of radioactivity were in the liver and perirenal fat, while the lowest concentration of H3 was in the brain.

Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations.

The rate at which diazepam returns to the central compartment from the deep peripheral compartment, k31, was shown to be the rate-controlling factor in the elimination of diazepAM and in the formation of desmethyldiazepam.

Determination of bromazepam in blood by electron-capture GLC and of its major urinary metabolites by differential pulse polarography.

Blood levels of bromazepam and the urinary excretion of the unchanged drug and its major metabolites were determined in humans following the administration of single 12-mg oral doses.

EEG and human psychopharmacology.

  • M. Fink
  • Psychology
    Annual review of pharmacology
  • 1969

Plasma concentrations of diazepam and of its metabolite N‐desmethyldiazepam in relation to anxiolytic effect

The results suggest that the degree of the diazepam effect is directly proportional to plasma concentrations and reCiprocal clearance values of diazepAM and N‐desmethyldiazepam.

Relation of EEG to blood levels of psychoactive drugs

  • Spectrum Publications
  • 1976