Blood levels and electroencephalographic effects of diazepam and bromazepam

  title={Blood levels and electroencephalographic effects of diazepam and bromazepam},
  author={M Fink and Peter Irwin and Robert E. Weinfeld and Morton A. Schwartz and A. H. Canney},
  journal={Clinical Pharmacology \& Therapeutics},
Blood levels and electroencephalographic (EEG) data were collected for 2 hr after single oral doses of bromazepam (9 mg), diazepam (10 mg), and placebo in 13 male adult volunteers. Both drugs caused an increase in beta activity (above 13 Hz) and a decrease in alpha activity (9 to 11 Hz) in the EEG. Blood levels of 100 nglml of diazepam or 50 ng Iml of bromazepam were associated with significant changes in EEG beta activity. Temporal changes in the EEG after administration of diazepam or… 

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