Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.

@article{Conforti2008BloodLO,
  title={Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.},
  author={Paola Conforti and Catarina Ramos and Barbara L. Apostol and Danielle A. Simmons and Huu Phuc Nguyen and Olaf Riess and Leslie M. Thompson and Chiara Zuccato and Elena Cattaneo},
  journal={Molecular and cellular neurosciences},
  year={2008},
  volume={39 1},
  pages={1-7}
}
Huntington's disease (HD) is an age-related neurodegenerative disorder that is currently untreatable. A prominent feature of HD pathology is the reduction of the pro-survival neurotrophin Brain-Derived Neurotrophic Factor (BDNF). Both mRNA and protein levels of BDNF are decreased in the brains of several HD rodent models and in human HD patients. We now report for the first time that this molecular event is mirrored in blood from HD rodent models. While protein levels of BDNF are undetectable… CONTINUE READING
21 Extracted Citations
43 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 21 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…