Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments.

@article{Cougoule2012BloodLA,
  title={Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environments.},
  author={C{\'e}line Cougoule and Emeline Van Goethem and V{\'e}ronique Le Cabec and Fanny 5 Lafouresse and Lo{\"i}c Dupr{\'e} and Vikram Mehraj and J M Mege and Claire Lastrucci and Isabelle Maridonneau-Parini},
  journal={European journal of cell biology},
  year={2012},
  volume={91 11-12},
  pages={938-49}
}
Leukocytes migrate through most tissues in the body, a process which takes place in 3D environments. We have previously shown that macrophages use the amoeboid migration mode in porous matrices such as fibrillar collagen I and the mesenchymal mode involving podosomes and matrix proteolysis in dense matrices such as Matrigel. Whether such a plasticity may apply to other leukocytes and to all subsets of macrophages is unknown. Here, we therefore provide a comparative analysis of the in vitro 3D… CONTINUE READING