Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population.

  title={Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population.},
  author={Lifang Hou and Hao Chun Wang and Samantha Sartori and Andrew Gawron and Jolanta Lissowska and Valentina Bollati and Letizia Tarantini and Fang Fang Zhang and Witold A. Zatoński and Wong-Ho Chow and Andrea A. Baccarelli},
  journal={International journal of cancer},
  volume={127 8},
Global hypomethylation has been shown to increase genome instability potentially leading to increased cancer risk. We determined whether global methylation in blood leukocyte DNA was associated with gastric cancer in a population-based study on 302 gastric cancer cases and 421 age- and sex-matched controls in Warsaw, Poland, between 1994 and 1996. Using PCR-pyrosequencing, we analyzed methylation levels of Alu and LINE-1, 2 CG-rich repetitive elements, to measure global methylation levels… CONTINUE READING
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