Blood histamine concentrations are not elevated in humans with septic shock.

@article{Jacobs1989BloodHC,
  title={Blood histamine concentrations are not elevated in humans with septic shock.},
  author={Roland Jacobs and Michael A. Kaliner and James H. Shelhamer and Joseph E. Parrillo},
  journal={Critical care medicine},
  year={1989},
  volume={17 1},
  pages={30-5}
}
Histamine has been suggested as an important mediator of the cardiovascular abnormalities during septic shock. To determine if blood histamine levels were increased during human sepsis and septic shock, plasma histamine was measured using a very sensitive radioenzyme assay employing histamine N-methyltransferase (HNMT) in the following patient groups: normal controls (n = 76), nonseptic critically ill (n = 12), nonseptic shock (n = 2), sepsis without shock (n = 28), and septic shock (n = 41… CONTINUE READING