Blood glucose-lowering nuclear receptor agonists only partially normalize hepatic gene expression in db/db mice.

@article{Loffler2006BloodGN,
  title={Blood glucose-lowering nuclear receptor agonists only partially normalize hepatic gene expression in db/db mice.},
  author={Michael Loffler and Martin Bilban and Mark Reimers and Werner Waldh{\"a}usl and Thomas Michael Stulnig},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 2},
  pages={797-804}
}
Agonists of the nuclear receptors peroxisome proliferator-activated receptor (PPAR) gamma, PPARalpha, and liver X receptors (LXRs) reduce blood glucose in type 2 diabetic patients and comparable mouse models. Since the capacity of these drugs to normalize hepatic gene expression is not known, we compared groups of obese diabetic db/db mice treated with agonists for PPARgamma [rosiglitazone (Rosi); 10 mg/kg/day], PPARalpha [Wy 14643 (Wy; 4-chloro-6-(2,3-xylidino)-2-pyrimidinyl)thioacetic acid… CONTINUE READING
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