Blood gene expression profiling detects silica exposure and toxicity.

  title={Blood gene expression profiling detects silica exposure and toxicity.},
  author={Rajendran Sellamuthu and Christina Umbright and Jenny R. Roberts and Rebecca Chapman and S H Young and Diana Richardson and Howard D Leonard and Walter McKinney and Bean T. Chen and David Frazer and Shengqiao Li and Michael L. Kashon and Pius Joseph},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={122 2},
Blood gene expression profiling was investigated as a minimally invasive surrogate approach to detect silica exposure and resulting pulmonary toxicity. Rats were exposed by inhalation to crystalline silica (15 mg/m³, 6 h/day, 5 days), and pulmonary damage and blood gene expression profiles were determined after latency periods (0-16 weeks). Silica exposure resulted in pulmonary toxicity as evidenced by histological and biochemical changes in the lungs. The number of significantly differentially… CONTINUE READING

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