Blood flow measurements with [(15)O]H2O and [18F]fluoride ion PET in porcine vertebrae.

  title={Blood flow measurements with [(15)O]H2O and [18F]fluoride ion PET in porcine vertebrae.},
  author={Morand Piert and Tilman T. Zittel and Hans Juergen Machulla and Georg A. Becker and Michael Jahn and G. Faris ' Robert S. Maier and Roland Bares and Horst Dieter Becker},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={13 8},
A dual positron emission tomography (PET) tracer study with [18F]fluoride and the freely diffusible tracer [(15)O]H2O was performed to measure the capillary transport of [18F]fluoride and to evaluate the potential of [18F]fluoride ion PET to quantitate bone blood flow. Under the condition of a high predictable single-pass extraction fraction (E(F)) for [18F]fluoride, the [18F]fluoride ion influx transport constant (K1F), derived from kinetic [18F]fluoride ion PET measurements, can be used to… CONTINUE READING
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