Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data.

@article{Mintun2001BloodFA,
  title={Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data.},
  author={Mark A. Mintun and Brian Nils Lundstrom and Abraham Z. Snyder and Andrei G. Vlassenko and Gordon L. Shulman and Marcus E. Raichle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 12},
  pages={6859-64}
}
Coupling of cerebral blood flow (CBF) and cerebral metabolic rate for oxygen (CMRO(2)) in physiologically activated brain states remains the subject of debates. Recently it was suggested that CBF is tightly coupled to oxidative metabolism in a nonlinear fashion. As part of this hypothesis, mathematical models of oxygen delivery to the brain have been described in which disproportionately large increases in CBF are necessary to sustain even small increases in CMRO(2) during activation. We have… CONTINUE READING
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