Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

@article{Horowitz2020BloodFT,
  title={Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain},
  author={Alana M. Horowitz and Xuelai Fan and Gregor Bieri and Lucas K. Smith and Cesar I. Sanchez-Diaz and Adam B. Schroer and Geraldine Gontier and Kaitlin Blackstone Casaletto and Joel H. Kramer and Katherine E. Williams and Saul A. Villeda},
  journal={Science},
  year={2020},
  volume={369},
  pages={167 - 173}
}
  • Alana M. Horowitz, Xuelai Fan, +8 authors Saul A. Villeda
  • Published 2020
  • Medicine
  • Science
  • Plasma transfers exercise benefit in mice Exercise has a broad range of beneficial healthful effects. Horowitz et al. tested whether the beneficial effects of exercise on neurogenesis in the brain and improved cognition in aged mice could be transferred in plasma (blood without its cellular components) from one mouse to another (see the Perspective by Ansere and Freeman). Indeed, aged mice that received plasma from young or old mice that had exercised showed beneficial effects in their brains… CONTINUE READING

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    C.) fellowships, an Irene Diamond AFAR postdoctoral fellowship

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    H. performed plasma administration and Gpld1 studies

    View/request a protocol for this paper from Bio-protocol

    are named as inventors on a patent application arising from this work. Data and materials availability: All data needed to understand and assess the conclusions of this study are

    assisted with Gpld1 studies

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    performed plasma administration studies