Blood eosinophils as a marker of response to inhaled corticosteroids in COPD.

@article{Barnes2016BloodEA,
  title={Blood eosinophils as a marker of response to inhaled corticosteroids in COPD.},
  author={Neil C. Barnes and Raj K Sharma and Sally Lettis and Peter M. A. Calverley},
  journal={The European respiratory journal},
  year={2016},
  volume={47 5},
  pages={1374-82}
}
Identification of a biomarker that predicts response to inhaled corticosteroids (ICS) would help evaluate the risk/benefit profile of ICS in chronic obstructive pulmonary disease (COPD) and guide treatment.The ISOLDE study randomised 751 patients (mean post-bronchodilator forced expiratory volume in 1 s (FEV1) 1.4 L: 50% predicted normal) to fluticasone propionate 500 μg twice daily or placebo for 3 years, finding no difference in FEV1 rate of decline between treatments (p=0.16) and a… CONTINUE READING