Blood cyanide and thiocyanate concentrations produced by long-term therapy with sodium nitroprusside.

@article{Vesey1985BloodCA,
  title={Blood cyanide and thiocyanate concentrations produced by long-term therapy with sodium nitroprusside.},
  author={Cyril Vesey and Peter V.Z. Cole},
  journal={British journal of anaesthesia},
  year={1985},
  volume={57 2},
  pages={
          148-55
        }
}
Blood cyanide (HCN) or plasma thiocyanate (SCN) concentrations, or both, were measured in 30 patients (ages 11 months-72 yr) receiving sodium nitroprusside (SNP) for 12-314 h. Sequential measurements in three of these patients (infused 5, 12 and 13 days) showed that HCN concentrations varied with dose rate, while SCN concentrations increased linearly with increasing SNP dose. The accumulated data confirmed that the rate of administration (0.3-6.5 micrograms kg-1 min-1) determined the plasma HCN… CONTINUE READING