Blood collection tubes influence serum ficolin-1 and ficolin-2 levels.

@article{Brady2014BloodCT,
  title={Blood collection tubes influence serum ficolin-1 and ficolin-2 levels.},
  author={Allison M Brady and Brady L. Spencer and Ann R Falsey and Moon H. Nahm},
  journal={Clinical and vaccine immunology : CVI},
  year={2014},
  volume={21 1},
  pages={51-5}
}
The ficolins are members of a recently discovered family of host innate opsonins that can activate the lectin pathway of complement. The ficolins bind many ligands, although they are typically described as binding acetylated sugars. Ficolin-1 (M-ficolin) and ficolin-2 (L-ficolin) are known to bind Streptococcus pneumoniae serotypes 19C and 11A, respectively. While studying the binding of ficolins to pneumococci, we found variations in ficolin-2 binding among serum samples collected in different… CONTINUE READING