Blood clearance in the rat of a recombinant mouse monoclonal antibody lacking the N-linked oligosaccharide side chains of the CH2 domains.

Abstract

The serum half-lives of a wild-type recombinant mouse monoclonal antibody of the IgG2b isotype and a mutant antibody differing from the wild-type antibody by a single amino acid substitution introduced into the CH2 domain, the replacement of Asn 297 by Ala to delete the conserved site of heavy chain glycosylation, were determined in the rat. The biological… (More)

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Cite this paper

@article{Wawrzynczak1992BloodCI, title={Blood clearance in the rat of a recombinant mouse monoclonal antibody lacking the N-linked oligosaccharide side chains of the CH2 domains.}, author={Edward J. Wawrzynczak and Alan J. Cumber and Geoffrey D. Parnell and P. T. Jones and G. Winter}, journal={Molecular immunology}, year={1992}, volume={29 2}, pages={213-20} }