Blood clearance and organ distribution of intravenously administered polymethacrylic nanoparticles in mice.

@article{rolland1989BloodCA,
  title={Blood clearance and organ distribution of intravenously administered polymethacrylic nanoparticles in mice.},
  author={alexandra. rolland and Brigitte Collet and Roger Le Verge and Louis Toujas},
  journal={Journal of pharmaceutical sciences},
  year={1989},
  volume={78 6},
  pages={481-4}
}
Polymethacrylic nanospheres (mean diameter 0.25-0.30 microns), prepared by aqueous emulsion copolymerization, were developed as a new site-specific drug delivery system. The nanoparticles were labeled either with indium-111 or iodine-125, and after a single iv injection of labeled particles into mice, their blood clearance and organ distribution were analyzed. A rapid clearance of 111In-labeled nanoparticles from the blood circulation to the mononuclear phagocyte system (MPS) was visualized… CONTINUE READING