Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis.

@article{Dallasta1999BloodbrainBT,
  title={Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis.},
  author={L M Dallasta and Liubomir A Pisarov and James E. Esplen and J V Werley and Ashlee V Moses and Jay A. Nelson and Cristian L. Achim},
  journal={The American journal of pathology},
  year={1999},
  volume={155 6},
  pages={1915-27}
}
The blood-brain barrier (BBB) plays a critical role in regulating cell trafficking through the central nervous system (CNS) due to several unique anatomical features, including the presence of interendothelial tight junctions that form impermeable seals between the cells. Previous studies have demonstrated BBB perturbations during human immunodeficiency virus encephalitis (HIVE); however, the basis of these permeability changes and its relationship to infiltration of human immunodeficiency… CONTINUE READING
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