Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion.

@article{Zhang2006BloodbrainBT,
  title={Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion.},
  author={Yun Zhang and William M Pardridge},
  journal={Brain research},
  year={2006},
  volume={1111 1},
  pages={227-9}
}
Intravenous brain-derived neurotrophic factor (BDNF) causes a 65-70% reduction in stroke volume in rats with the middle cerebral artery occlusion (MCAO), provided the BDNF is conjugated to a blood-brain barrier (BBB) molecular Trojan horse. The latter may be a peptidomimetic monoclonal antibody (MAb) to the transferrin receptor. The present studies… CONTINUE READING