Blood-brain barrier genomics.

@article{Li2001BloodbrainBG,
  title={Blood-brain barrier genomics.},
  author={Ji Li and Ruben J. Boado and William M Pardridge},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2001},
  volume={21 1},
  pages={
          61-8
        }
}
The blood-brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate tester cDNA. A polymerase chain reaction-based subtraction cloning method, suppression subtractive hybridization (SSH), was used, and the BBB cDNA… CONTINUE READING

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Blood-brain barrier genomics

  • JY Li, RJ Boado, WM. Pardridge
  • J Cereb Blood Flow Metab
  • 2001

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