Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases.

@article{Simons1998BloodBB,
  title={Blood brain barrier endothelial cells express candidate amyloid precursor protein-cleaving secretases.},
  author={Elizabeth R. Simons and Dawn C. Marshall and Heidi J Long and Katja Otto and Andrea M Billingslea and Heather E Tibbles and John M. Wells and Patricia B. Eisenhauer and Richard E. Fine and David H. Cribbs and Thomas A. Davies and Carmela R. Abraham},
  journal={Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis},
  year={1998},
  volume={5 3},
  pages={153-62}
}
Proteolytic cleavage of the amyloid precursor protein (A beta PP) results in the generation of the amyloidogenic fragment known as amyloid beta peptide (A beta). Deposition of A beta in the brain parenchyma and cerebrovasculature is a feature of Alzheimer's disease (AD). To date, the process whereby A beta is generated and deposited remains unclear. We have previously established that activated platelets from AD patients retain more A beta PP on their surface than control platelets. We report… CONTINUE READING