Blood-brain barrier efflux transport.

@article{Golden2003BloodbrainBE,
  title={Blood-brain barrier efflux transport.},
  author={Pamela L Golden and Gary M. Pollack},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 9},
  pages={
          1739-53
        }
}
Efflux transport at the blood-brain barrier (BBB) limits the brain tissue exposure to a variety of potential therapeutic agents, including compounds that are relatively lipophilic and would be predicted to permeate the endothelial lining of the brain microvasculature. Recent advances in molecular and cell biology have led to identification of several specific transport systems at the blood-brain interface. Refinement of classical pharmacokinetic experimentation has allowed assessment of the… CONTINUE READING
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