Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion.

@article{Ueno2002BloodbrainBD,
  title={Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion.},
  author={Masaki Ueno and Hidekazu Tomimoto and Ichiro Akiguchi and Hideaki Wakita and Haruhiko Sakamoto},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2002},
  volume={22 1},
  pages={97-104}
}
Blood-brain barrier damage has been implicated in the pathogenesis of cerebrovascular white matter lesions. This type of lesion is responsible for cognitive impairment in the elderly and can be induced by permanent ligation of the bilateral common carotid arteries in the rat. Because it is unclear whether the blood-brain barrier is impaired, we examined whether vascular permeability to horseradish peroxidase is altered using this model. According to light microscopic results, the reaction… CONTINUE READING

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