Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: protective effect by estradiol treatment in ovariectomized animals.

@article{TomsCamardiel2005BloodbrainBD,
  title={Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: protective effect by estradiol treatment in ovariectomized animals.},
  author={Mayka Tom{\'a}s-Camardiel and Jose Luis Venero and Anthony J Herrera and Roc{\'i}o M. de Pablos and J. A. Pintor-Toro and Alberto Machado and Jose Ygnacio Pastor Ca{\~n}o},
  journal={Journal of neuroscience research},
  year={2005},
  volume={80 2},
  pages={235-46}
}
Strong evidence involves aquaporin-4 (AQP4) in the physiopathology of brain edema. Two major points remain unsolved: (1) the capacity of perivascular glial cells to regulate AQP4 in response to disruption of the blood-brain barrier (BBB); and (2) the potential beneficial role of AQP4 in the clearance of brain edema. We used intraparenchymal injection of lipopolysaccharide (LPS) as an efficient model to induce BBB disruption. This was monitored by IgG extravasation and AQP4 was studied at the… CONTINUE READING
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