Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-α in the rat

@article{Wright2005BloodbrainBC,
  title={Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-$\alpha$ in the rat},
  author={James L. Wright and Randall E. Merchant},
  journal={Journal of Neuro-Oncology},
  year={2005},
  volume={20},
  pages={17-25}
}
SummaryHuman recombinant tumor necrosis factor-α (rTNF-α) was administered to normal Fischer 344 rats by stereotaxic intracerebral (IC) injection. Animals receiving a single injection of either 6 x 104 U rTNF-α or an equivalent volume of excipient (vehicle) in their right parietal lobe. In order to demonstrate any effects rTNF-α might have on the blood-brain barrier (BBB), two studies were conducted, one employing exogenous horseradish peroxidase (HRP, 44 kD) as a tracer of BBB permeability and… 

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