Blood-brain barrier alterations in ageing and dementia

@article{Popescu2009BloodbrainBA,
  title={Blood-brain barrier alterations in ageing and dementia},
  author={B. Popescu and E. C. Toescu and L. Popescu and O. Bajenaru and N. Bogdanovic},
  journal={Journal of the Neurological Sciences},
  year={2009},
  volume={283},
  pages={99-106}
}
The current pathogenic scenarios of different types of dementia are based on a number of common mechanisms of neurodegeneration, such as accumulation of abnormal proteins (within or outside cells), mitochondrial dysfunction and oxidative stress, calcium homeostasis dysregulation, early synaptic disconnection and late apoptotic cell death. Ageing itself is associated with mild cognitive deterioration, probably due to subtle multifactorial changes resulting in a global decrease of a functional… Expand
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