Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency.

@article{Calingasan1995BloodbrainBA,
  title={Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency.},
  author={Noel Ylagan Calingasan and Harriet D Baker and K F Sheu and Gary E Gibson},
  journal={Experimental neurology},
  year={1995},
  volume={134 1},
  pages={64-72}
}
Experimental thiamine deficiency (TD) is a classical model of metabolic encephalopathy and selective cell loss in the brain resulting from a generalized, low-grade oxidative deficit. Late stages of TD are characterized by hemorrhages in the brain indicating a disruption of the blood-brain barrier (BBB). However, the relation of the breakdown of the BBB to selective cell loss in TD is not understood. The current studies examined the BBB at different stages of TD using immunoglobulin G (IgG) as… CONTINUE READING