Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration.

@article{Bartels2009BloodbrainBP,
  title={Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration.},
  author={Anna L. Bartels and Rudie Kortekaas and Joost Bart and Antoon T. M. Willemsen and Onno L de Klerk and Jeroen J de Vries and Joost C H van Oostrom and Klaus Leonhard Leenders},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 11},
  pages={1818-24}
}
Cerebrovascular P-glycoprotein (P-gp) acts at the blood-brain barrier (BBB) as an active cell membrane efflux pump for several endogenous and exogenous compounds. Age-associated decline in P-gp function could facilitate the accumulation of toxic substances in the brain, thus increasing the risk of neurodegenerative pathology with aging. We hypothesised a regionally reduced BBB P-gp function in older healthy subjects. We studied cerebrovascular P-gp function using [(11)C]-verapamil positron… CONTINUE READING

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