Blood-borne tissue factor: another view of thrombosis.

  title={Blood-borne tissue factor: another view of thrombosis.},
  author={Peter L A Giesen and Ursula Rauch and Bernd Bohrmann and Doroth{\'e}e Kling and Merc{\'e} Roqu{\'e} and John T. Fallon and Juan Jose Badimon and Jacques Himber and Markus A. Riederer and Yale Nemerson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 5},
Arterial thrombosis is considered to arise from the interaction of tissue factor (TF) in the vascular wall with platelets and coagulation factors in circulating blood. According to this paradigm, coagulation is initiated after a vessel is damaged and blood is exposed to vessel-wall TF. We have examined thrombus formation on pig arterial media (which contains no stainable TF) and on collagen-coated glass slides (which are devoid of TF) exposed to flowing native human blood. In both systems the… CONTINUE READING
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