Blood-borne, albumin-bound prostaglandin E2 may be involved in fever.

  title={Blood-borne, albumin-bound prostaglandin E2 may be involved in fever.},
  author={Andrej A. Romanovsky and Andrey I Ivanov and Elena K Karman},
  journal={The American journal of physiology},
  volume={276 6},
Although the involvement of blood-borne PGE2 in fever has been hypothesized by several authors and has substantial experimental support, the current literature often rejects this hypothesis because several attempts to induce fever by a peripheral PGE2 failed. However, it is usually ignored that the amphipathic molecules of PGE2 are readily self-associating and that such an aggregation could have prevented the peripherally administered PGE2 (free form) from expressing its pyrogenic activity… CONTINUE READING


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