Blood-borne, albumin-bound prostaglandin E2 may be involved in fever.

@article{Romanovsky1999BloodborneAP,
  title={Blood-borne, albumin-bound prostaglandin E2 may be involved in fever.},
  author={Andrej A. Romanovsky and Andrey I Ivanov and Elena K Karman},
  journal={The American journal of physiology},
  year={1999},
  volume={276 6},
  pages={
          R1840-4
        }
}
Although the involvement of blood-borne PGE2 in fever has been hypothesized by several authors and has substantial experimental support, the current literature often rejects this hypothesis because several attempts to induce fever by a peripheral PGE2 failed. However, it is usually ignored that the amphipathic molecules of PGE2 are readily self-associating and that such an aggregation could have prevented the peripherally administered PGE2 (free form) from expressing its pyrogenic activity… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

All About Albumin: Biochemistry, Genetics and Medical Applications

  • T. Peters, Jr.
  • San Diego, CA: Academic,
  • 1996
Highly Influential
5 Excerpts

Prostaglandin E2: a putative fever mediator. In: Fever: Basic Mechanisms and Management (2nd ed.), edited by P.A

  • C. M. Blatteis, E. Sehic
  • 1997
Highly Influential
11 Excerpts

Prostaglandin, the OVLT and fever. In: NeuroImmunology of Fever, edited by T

  • J. T. Stitt
  • Bartfai and D. Ottoson. Oxford, UK: Pergamon,
  • 1992
Highly Influential
8 Excerpts

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