Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity

@article{Grattan2003BloodBN,
  title={Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity},
  author={Clive E Grattan and Garcia Dawn and Sdj Gibbs and David M. Francis},
  journal={Clinical \& Experimental Allergy},
  year={2003},
  volume={33}
}
Background The basopenia of chronic urticaria relates to histamine releasing autoantibodies in the serum of patients with autoimmune urticaria. This reduction in circulating basophils may be due to active recruitment into weals. If so, it might be expected that numbers in blood would be reduced when urticaria is active and increased after treatment. The primary aim of this study was to look at diurnal variation of basophil numbers in patients with chronic ordinary urticaria (not physical or… 

Basophils and mast cells in chronic idiopathic urticaria

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Basophil histamine release activity and disease severity in chronic idiopathic urticaria.

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The Potential Role of Basophils in Urticaria

This analysis of a case of urticaria refractory to antihistamine therapy in which the peripheral-blood basophil count responded to omalizumab therapy and its withdrawal and showed an unexpected increase in the expression of a cell surface activation marker, it is proposed that activated basophils migrate to the local skin area and cause their stay in the peripheral blood.

Progress and Challenges in the Understanding of Chronic Urticaria

  • M. FerrerA. Kaplan
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  • 2007
Basophils of all chronic urticaria patients (autoimmune or idiopathic) are hyperresponsive to serum, regardless of source, but poorly responsive to anti IgE.

Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin

Results suggest that one reason for the decrease of basophil numbers in the peripheral blood in CSU may involve migration of circulating basophils into the skin.

Autoimmune Theories of Chronic Spontaneous Urticaria

Evidence surrounding the autoimmune pathogenesis of chronic urticaria is highlighted including recent data which suggests that CSU may involve contributions from both immunoglobin G (IgG)-specific and immunoglobulin E (IGE)-specific autoantibodies against a vast array of antigens that can span beyond those found on the surface of mast cells and basophils.

Aetiopathogenesis of Urticaria

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  • 2021
Functional autoantibodies can be demonstrated in about 50% of patients with ordinary spontaneous chronic urticaria and the role for inflammatory cells in urticarial lesions needs further investigation.

Relation between Autoimmunity Chronic Urticaria and the Levels of Plasma Prothrombin F1+2

The study explored the relation between autoimmunity (CU) and the levels of plasma prothrombin F1+2 in patients with positive autologous serum skin test (APST) and found that the levels have decreased obviously after treatment.
...

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