Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity

  title={Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activity},
  author={Clive E Grattan and Garcia Dawn and Sdj Gibbs and David M. Francis},
  journal={Clinical \& Experimental Allergy},
Background The basopenia of chronic urticaria relates to histamine releasing autoantibodies in the serum of patients with autoimmune urticaria. This reduction in circulating basophils may be due to active recruitment into weals. If so, it might be expected that numbers in blood would be reduced when urticaria is active and increased after treatment. The primary aim of this study was to look at diurnal variation of basophil numbers in patients with chronic ordinary urticaria (not physical or… 

Basophils and mast cells in chronic idiopathic urticaria

It is proposed that in addition to autoantibodies, specific differences in the expression of FcaRI-signaling molecules in the basophils or mast cells of CIU patients may contribute to the generation of urticarial eruptions.

Basophil histamine release activity and disease severity in chronic idiopathic urticaria.

  • R. BakerK. Vasagar S. Saini
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2008

The Potential Role of Basophils in Urticaria

This analysis of a case of urticaria refractory to antihistamine therapy in which the peripheral-blood basophil count responded to omalizumab therapy and its withdrawal and showed an unexpected increase in the expression of a cell surface activation marker, it is proposed that activated basophils migrate to the local skin area and cause their stay in the peripheral blood.

Progress and Challenges in the Understanding of Chronic Urticaria

  • M. FerrerA. Kaplan
  • Medicine, Biology
    Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
  • 2007
Basophils of all chronic urticaria patients (autoimmune or idiopathic) are hyperresponsive to serum, regardless of source, but poorly responsive to anti IgE.

Decreased peripheral basophil counts in urticaria and mouse model of oxazolone-induced hypersensitivity, the latter suggesting basopenia reflecting migration to skin

Results suggest that one reason for the decrease of basophil numbers in the peripheral blood in CSU may involve migration of circulating basophils into the skin.

Autoimmune Theories of Chronic Spontaneous Urticaria

Evidence surrounding the autoimmune pathogenesis of chronic urticaria is highlighted including recent data which suggests that CSU may involve contributions from both immunoglobin G (IgG)-specific and immunoglobulin E (IGE)-specific autoantibodies against a vast array of antigens that can span beyond those found on the surface of mast cells and basophils.

Aetiopathogenesis of Urticaria

  • C. Grattan
  • Medicine, Biology
    Urticaria and Angioedema
  • 2021
Functional autoantibodies can be demonstrated in about 50% of patients with ordinary spontaneous chronic urticaria and the role for inflammatory cells in urticarial lesions needs further investigation.

Relation between Autoimmunity Chronic Urticaria and the Levels of Plasma Prothrombin F1+2

The study explored the relation between autoimmunity (CU) and the levels of plasma prothrombin F1+2 in patients with positive autologous serum skin test (APST) and found that the levels have decreased obviously after treatment.



Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activity

  • C. GrattanD. Walpole R. Barr
  • Medicine, Biology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1997
Background and Objective Peripheral blood basophils are reduced in some chronic urticaria patients when counted with granule stains and the relationship between basophil numbers in vivo and serum histamine releasing activity has not been studied.

Randomized double‐blind study of cyclosporin in chronic ‘idiopathic’ urticaria

This study shows that cyclosporin is effective for chronic urticaria and provides further evidence for a role of histamine‐releasing autoantibodies in the pathogenesis of this chronic ‘idiopathic’ disease.

Defective histamine release in chronic urticaria.

Chronic urticaria patients have a defect in leukocyte histamine release that occurs after the anti-IgE-IGE interaction, but before the actual (second-stage) release process, and that is comparable to the phenomenon of desensitization.

The autologous serum skin test: a screening test for autoantibodies in chronic idiopathic urticaria

The parameters of the ASST are determined which define the optimal sensitivity and specificity for the identification of patients with autoantibodies and the following subjects had positive ASSTs: none of 15 dermographics, none of 10 atopics, one of nine cholinergics and one of 40 controls.


The purpose of the present investigation was to ascertain whether the occurrence and severity of basopenia is dependent on the form of urticaria and/or the type, severity and duration of the symptoms.

Immune Aberrations in B and T Lymphocytes Derived from Chronic Urticaria Patients

Increased proliferation accompanies the finding that activated B and T lymphocytes from these patients demonstrate increased bcl-2 expression, which provides further evidence that CU is indeed an autoimmune disease, although its precise nature has yet to be fully elucidated.

Basophils in bronchial asthma with reference to reagin‐type allergy

It was found that the basophils were increased in those patients with allergic asthma whose sera gave positive Prausnitz‐Küstner reactions, and this study suggests a significant relationship of peripheral blood basophil with the allergic reaction.

Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria.

Histamine-releasing IgG autoantibodies against the alpha subunit of the high-affinity IgE receptor are present in the circulation of some patients with chronic urticaria.