Blood bank conditions and RBCs: the progressive loss of metabolic modulation

@article{Messana2000BloodBC,
  title={Blood bank conditions and RBCs: the progressive loss of metabolic modulation},
  author={Irene Messana and Lucietta Ferroni and Francesco Misiti and Gabriella Girelli and Simonetta Pupella and Massimo Castagnola and Bruno Zappacosta and Bruno Giardina},
  journal={Transfusion},
  year={2000},
  volume={40}
}
BACKGROUND: Human RBC metabolism is modulated by the cell oxygenation state. Among other mechanisms, competition of deoxyhemoglobin and some glycolytic enzymes for the cytoplasmic domain of band 3 is probably involved in modulation. This metabolic modulation is connected to variations in intracellular NADPH and ATP levels as a function of the oxygenation state of the cell, and, consequently, it should have physiologic relevance. The present study investigates the effect of storage on this… Expand
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